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Gwyneth Paltrow

Donna

Christina Applegate

Christine

Mark Ruffalo

Ted

Candice Bergen

Sally Weston

Joshua Malina

Randy

Kelly Preston

Sherry

Rob Lowe

Pilot Steve

Mike Myers

John

Marc Blucas

Tommy Boulay

Stacey Dash

Angela

Jon Polito

Roy Roby

Concetta Tomei

Mrs. Stewart

Robyn Peterson

Donna's Mom

Nadia Dajani

Paige

Frederick Coffin

Mr. Stewart

Chelsey Cole

Six-Year-Old Donna

Troy Evans

Customer

David Hayward

Pete

Jorge R. Hernandez

Spanish Man

Duane King

Royalty Operations Clerk

Christina Malpero

Rita

Merrilee McCommas

June

Mary McNeal

Ted's Study Partner

Stephanie Miller

TV Interviewer

Susan Mosher

Senior Flight Attendant

Emile Ohayon

French First Class Man

Daniel Raymont

British Man

DonnaMarie Recco

Tammy

Matt Roth

Greg

Connie Sawyer

Grandma Stewart

Priscilla Inga Taylor

Janette

Jon Tenting

Donna's Co-Pilot

Jeff Yagher

Ghost Rider

Jessica Capshaw

Flight Attendant (uncredited)

George Kennedy

Passenger Requesting Vodka (uncredited)

Victoria Garcia-Kelleher

Clerk #1 (uncredited)

Stephen Tobolowsky

Frank Thomas (uncredited)

Anastacia Spiegel

Runway Model at Airport (uncredited)

Valentin Siroon

Flight Attendant Trainee (uncredited)

Amy Oberer

Flight Attendant Trainee (uncredited)

Amanda Wycoff

Flight Attendant Trainee (uncredited)

Dawn-Marie Whelan

Flight Attendant Trainee (uncredited)

Greg Bronson

Fashion Photographer (uncredited)

Roark Critchlow

Tennis Pro (uncredited)

Chad Everett

Jack Weston (uncredited)

Wayne Federman

Whiskey Sour Man (uncredited)

Clarinda Ross

Diaper Woman (uncredited)

Jackie Zane

Passenger in Terminal (uncredited)

Candice T. Cain

CDG Passenger (uncredited)

Bruno Barreto

Chitra F. Mojtabai